منابع مشابه
How mitochondria produce reactive oxygen species
The production of ROS (reactive oxygen species) by mammalian mitochondria is important because it underlies oxidative damage in many pathologies and contributes to retrograde redox signalling from the organelle to the cytosol and nucleus. Superoxide (O2(*-)) is the proximal mitochondrial ROS, and in the present review I outline the principles that govern O2(*-) production within the matrix of m...
متن کاملO 22: Reactive Oxygen Species and Epilepsy
Seizure activity has been proposed to result in the generation of reactive oxygen species (ROS), which then contribute to seizure-induced neuronal damage and eventually cell death. Although the mechanisms of seizure-induced ROS generation are unclear, mitochondria and cellular calcium overload have been proposed to have a crucial role. We aim to determine the sources of seizure-induced ROS and ...
متن کاملReactive Oxygen Species Regulate Protrusion Efficiency by Controlling Actin Dynamics
Productive protrusions allowing motile cells to sense and migrate toward a chemotactic gradient of reactive oxygen species (ROS) require a tight control of the actin cytoskeleton. However, the mechanisms of how ROS affect cell protrusion and actin dynamics are not well elucidated yet. We show here that ROS induce the formation of a persistent protrusion. In migrating epithelial cells, protrusio...
متن کاملTitle: Reactive Oxygen Species Regulate Activity-Dependent Neuronal Structural Plasticity
1 in Drosophila 2 3 Authors: Matthew C. W. Oswald1*, Paul S. Brooks1, Maarten F. Zwart2, Amrita Mukherjee1, 4 Ryan J. H. West3, Khomgrit Morarach1, Sean T. Sweeney3, Matthias Landgraf1* 5 *Correspondence to: [email protected] and [email protected] 6 7 8 Affiliations: 9 1 University of Cambridge, Department of Zoology, Downing Street, Cambridge, CB2 3EJ, 10 United Kingdom 11 2 HHMI Janelia Researc...
متن کاملHIF and reactive oxygen species regulate oxidative phosphorylation in cancer.
A decrease in oxidative phosphorylation (OXPHOS) is characteristic of many cancer types and, in particular, of clear cell renal carcinoma (CCRC) deficient in von Hippel-Lindau (vhl) gene. In the absence of functional pVHL, hypoxia-inducible factor (HIF) 1-alpha and HIF2-alpha subunits are stabilized, which induces the transcription of many genes including those involved in glycolysis and reacti...
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ژورنال
عنوان ژورنال: Journal of Biomolecular Research & Therapeutics
سال: 2014
ISSN: 2167-7956
DOI: 10.4172/2167-7956.1000e130